This book summarizes the development of highly tolerant cultivars via plant breeding, genomics, and proteomic approaches. This book could supplement data for budding researchers by providing extensive ongoing measures to improve the detoxification competence of appropriate species via wide range of plant improvement approaches. It also offers insights into heavy metal signalling,metal chelation by organic acids, amino acids, and phosphate derivatives, and illustrates other strategies that have been extensively investigated, such as genetic engineering, ecological improvement of the rhizosphere using mycorrhiza and chelator enhanced phytoremediation technology. This book could provide simple anthology for undergraduate and postgraduate students to understand fundamentals of heavy metal pollution in the environment. The book closes with a prelude to an inclusive study of biodiversity that could provide new biofilters for metal detoxification.