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COARSE-GRAINED MODELLING OF DNA AND DNA

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Sinopse

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

Detalhes do Produto

    • Ano de Edição: 2012
    • Ano:  2016
    • País de Produção: Canada
    • Código de Barras:  2001119362513
    • ISBN:  9783642305177

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