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FORMATION AND COOPERATIVE BEHAVIOUR OF PROTEIN

COMPLEXES ON THE CELL MEMBRANE


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Sinopse

With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

Detalhes do Produto

    • Formato:  ePub
    • Subtítulo:  COMPLEXES ON THE CELL MEMBRANE
    • Origem:  IMPORTADO
    • Editora: KOBO EDITIONS
    • Coleção:  Springer Theses
    • Assunto: Biologia
    • Idioma: INGLÊS
    • Ano de Edição: 2011
    • Ano:  2016
    • País de Produção: Canada
    • Código de Barras:  2001026302190
    • ISBN:  9783642239885

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