Aguarde...

BIOISOSTERES IN MEDICINAL CHEMISTRY


R$ 296,50

em até 9x de R$ 32,94 sem juros no cartão, ver mais opções

Produto disponível no mesmo dia no aplicativo Kobo, após a confirmação  do pagamento!

Sinopse

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third partcovers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays ofprotein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Detalhes do Produto

    • Edição:  1
    • Ano de Edição: 2012
    • Ano:  2016
    • País de Produção: Canada
    • Código de Barras:  2001120175782
    • ISBN:  9783527654321

Avaliação dos Consumidores

ROLAR PARA O TOPO