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COMPREHENSIVE ANALYSIS OF PARASITE BIOLOGY

FROM METABOLISM TO DRUG DISCOVERY


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Sinopse

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Detalhes do Produto

    • Coleção:  Drug Discovery in Infectious Diseases
    • Edição:  1
    • Ano de Edição: 2016
    • Ano:  2016
    • País de Produção: Canada
    • Código de Barras:  2001026995422
    • ISBN:  9783527694112

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