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Imaging Informatics Professionals (IIPs) have come to play an indispensable role in modern medicine, and the scope of this profession has grown far beyond the boundaries of the PACS. A successful IIP must not only understand the PACS itself, but also have knowledge of clinical workflow, a base in several medical specialties, and a solid IT capability regarding software interactions and networking. With the introduction of a certification test for the IIP position, a single source was needed to explain the fundamentals of imaging informatics and to demonstrate how those fundamentals are applied in everyday practice. Practical Imaging Informatics describes the foundations of information technology and clinical image management, details typical daily operations, and discusses rarer complications and issues.