Lymphocytes play a prominent role in the combat of infectious diseases. FOr a sufficient but limited immune response it is essential that migration and activation of lymphocytes are strictly controlled. THe transcription factor KLF2 modulates T lymphocyte egress from lymphoid organs by regulating S1P1. THis is not the case for B cells. INstead, KLF2 regulates homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of 7 integrin. IN mice with a B cell-specific deletion of KLF2, S1P1 expression on B cells was only slightly affected. ACcordingly, all splenic B cell subsets were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. IN contrast, fewer peyers patches harboring less B cells, fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were found. UPon thymus-dependent immunization, IgG titers were diminished and antigen-specific plasma cells were absent in the bone marrow. FUrthermore this study provides first evidence that KLF2 is posttranslationally phosphorylated directly or indirectly by the PI3K signaling pathway.
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Subtítulo: INVESTIGATIONS ON THE FUNCTION OF KRUPPEL-LIKE FAC