'Immunobiology', Fifth Edition guides the reader through the immune system in all its aspects - from the first engagement of innate immunity to the generation of the adaptive immune reponse and its clinical consequences. The Fifth Edition is an extensive revision which includes new material and major insights, improved logical progression of topics due to new discoveries, and an emphasis on unifying principles. Immunobiology sets the standard for currency and authority with its clear writing style and organization, full-color art program, scientific accuracy, frequent updates, and consistent viewpoint - that of the host's interaction with an environment containing many species of potentially harmful microorganisms. The innate immune mechanisms that form the front line of host defense against infection now occupy a new chapter at the beginning of the book. The chapters describing the antigen-receptors of B and T lymphocytes and the generation of diversity in their antigen-binding regions have been reorganized to emphasize unifying concepts that apply to both B and T cell receptors. There is now a single chapter on lymphocyte development that extends its unified approach to B and T cell development to a consideration of the survival and maturation of lymphocytes in peripheral lymphoid tissues. The discussion of T cell and B cell effector functions have been kept separate. Chapter 10 treats the immune system as a whole, integrated system and synthesizes the material in the previous chapters. A substantial new chapter section devoted to the mucosal immune system describes how the mucosa-associated lymphoid tissues have a distinctive anatomy and repertoire of lymphocytes, and how they function as a separate compartment of the peripheral immune system. Later chapters focus on applications and various clinical situations. Contains a new afterword on the evolution of the immune system and the future of immunology.
Detalhes do Produto
Subtítulo: THE IMMUNE SYSTEM IN HEALTH AND DISEASE