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This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. 'Bioseparation of Proteins' provides a background of the bioseparation processes, and emphasizes the influence of the different bioseparation processes on protein inactivation. The book covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. Topics include separation and detection methods; estimates of protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various bioseparation processes and quality control procedures.