This invaluable book considers the most important questions that arise during such a study and gives approaches to their solutions. Validation: Do the present guidelines yield reliable results and are they sufficient? How can modelling of bioconcentration be performed? Can the bioaccumulation potential of a chemical be predicted by Quantitative Structure-Activity Relationships (QSARs)? Extrapolation: Can test results be extrapolated between organism groups? Can laboratory results be extrapolated to environmental conditions and vice-versa? Is a distinction between bioconcentration and biomagnification necessary? Evaluation: Does bioaccumulation reflect toxicity? How can data on bioaccumulation be evaluated differentially? What are the current approaches to assess bioaccumulation; are they capable of further development? International experts from industry, government and research give opinions and statements on these complex questions.