When the first planes go down - in Europe, in California, in Asia - authorities blame terrorists. All flights are grounded as world leaders try to figure out how the global assault has been coordinated. And when cars, ships, and factories stop running too, it becomes clear that the common link is oil. Somehow a microbe, genetically engineered to destroy petroleum, has infected the world supply. Dr. Gregory Gillette, an epidemiologist with the Centers for Disease Control, is a disease hunter specializing in microbes that attack human beings. When the Pentagon taps him to be part of the Rapid Response Team assembled to track and kill the devastating Delta-3 bacteria, he quickly discovers that his expertise is ignored, his presence meaningless. The leader of the task force is an old nemesis who sidelines Gillette. Gillette returns home to Washington, where he watches in horror as food becomes scarce, neighbor attacks neighbor, and government collapses. With winter approaching, the capital faces anarchy and Gillette faces a choice - to stay with his family or to disobey orders and find the microbes' antidote through clues that may not even be real.