After the death of his half brother, Stefan, at the hands of Vlad Tsepesh - also known as Dracula - and after the destruction of his vampire father, Arkady, also at the hands of Vlad, Abraham van Helsing has traveled the world slaying many vampires. With every vampire he destroys, Bram becomes stronger and Vlad weaker, and soon Bram hopes he will be able to finally kill the fearsome vampire who has kept the Tsepesh family enslaved through a centuries-old blood ritual. But a desperate Vlad and his vampire great-niece, Zsuzanna, summon help from the most powerful, brutal, and beautiful vampire of all - Countess Elizabeth of Bathory. Bram learns of their plot to destroy him, and makes his own move to strike out at Vlad before Vlad can put him to death. He teams up with a courageous band of humans as he hunts Vlad - including Mina Harker and John Seward - and they finally succeed in killing the head of the Tsepesh clan, just as Bram Stoker foretold in Dracula.