April 26, 1478. Giuliano de Medici, brother of Lorenzo the Magnificent, the head of the powerful Florentine Medici family, is assassinated. Ten years later, a young Lisa Gherardini listens to the story of Giuliano's death, unaware of the significance it holds for her future. Drawn into the Medici circle by her passion for the Arts, Lisa meets the Medici's most luminescent friend - da Vinci. Against the turbulent backdrop of Savonarola's Florence, the two become conspirators and eventually each other's saviours in this parallel love story of infinite twists.