In the grip of a midlife crisis at twenty-eight, Dwight B. Wilmerding is also afflicted with a chronic inability to make up his mind. Encouraged to try an experimental drug meant to banish indecision. Dwight jumps at the chance (not without some meditation on the hazards of jumping) and swallows the first fateful pill. And when all at once he is 'pfired' from his tech job at Pfizer and invinted to rendezvous in exotic Ecuador with the girl of his long-ago prep-school dreams, he finds himself on the brink of a new life. The trouble is that Dwight can't decide if the pills are working. Now, deep in the jungles of the Amazon, his would-be romantic escape becomes a hilarious journey into unbidden responsibility and unwelcome knowledge - and an unexpected raison d'être.