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    Concerns itself with the methods for screening novel ligands for GPCRs, particularly endogenous ligands for orphan GPCRs including odorant receptors. Includes a simple ligand screening method using the fusion protein of GPCRs with G protein alpha subunits. Presents a method of systematic mutagenesis of muscarinic receptors to reveal the structure-function relationship, as well as a method to generate and analyze knockout mice using muscarinic receptors as a model. Discusses desensitization, particularly internalization of muscarinic receptors, valuable to those researching other GPCRs. Includes discussion on oligomerization of GPCRs, particularly of purinergic receptors. Shares highly useful information on the crystallization of rhodopsin, the only GPCR that has had its atomic structure revealed. Offers a unique approach- the single molecule detection technique - that is applied to cAMP receptors involved in the chemotactic response of Dictyostelium cells. Investigates the structure of ligands bound to GPCRs and computer models for the interaction of GPCRs and their ligands. This book provides a broad base of knowledge of 'G-protein-coupled receptors'. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

    Detalhes do Produto

      • Edição:  1
      • Ano de Edição: 2005
      • Ano:  2005
      • País de Produção: United States
      • Código de Barras:  9780849327711
      • ISBN:  0849327717
      • Encadernação:  CAPA DURA
      • Altura: 23.50 cm
      • Largura: 15.90 cm
      • Nº de Páginas:  315

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