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Santiago Ramon y Cajal was a mythic figure in science. Hailed as the father of modern anatomy and neurobiology, he was largely responsible for the modern conception of the brain. In addition to leaving a legacy of unparalleled scientific research, Cajal sought to educate the novice scientist about how science was done and how he thought it should be done. This rediscovered classic, first published in 1897, is a still-relevant anecdotal guide that offers timeless advice not only for the new investigator but for the old pro as well.