A thought tradition, like that of the philosophies of India, tends to fall in the stereotype of systems and doctrines. But the dynamics of understanding demand fresh interpretations, relating contents and strands of classical Indian philosophy to themes and concerns of present-day thought. Drawing from mainstream Vedanta and allied areas, this study focuses on the crucial question of 'human' significance. This guiding motive is examined in thematic interaction with a range of relevant topics on methodology, knowledge and most importantly, human condition. The explorations, based on source materials, offer critical reflections across the arena of East-West thought.